Dermatophytosis caused by Tricophyton rubrum as an opportunistic infection in patients with Cushing disease.
نویسندگان
چکیده
Trichophyton rubrum is a common agent found in superficial mycoses, which present ample non-inflammatory lesions, with chronic evolution, especially in immunocompromised patients. The hypercortisolism in Cushing's syndrome increases the risk of infections as a result of the immunosuppressive effect of glucocorticoids. The reported cases here refer to two different types of dermatophytosis caused by Trichophyton rubrum in patients with Cushing's disease, resistant to antifungal treatment. The disease remitted after the levels of cortisol went back to normal.
منابع مشابه
Trichophyton rubrum dermatophytosis in a patient under chronic use of systemic corticoids: an exuberant presentation*
A 71-year-old female white patient had a 6-month history of annular, non-pruritic, erythematous plaques, measuring up to 12 cm in diameter, on her face, scalp, neck and arms. (Figure 1). On examination, the patient had Cushingoid features. She reported having an unspecifi ed endocrinopathy, for which she had been on continuous use of prednisone (25 mg/day) for 6 years. To make the diagnosis, we...
متن کاملTrichophyton rubrum tinea capitis in an HIV-positive patient with generalized dermatophytosis
INTRODUCTION Generalized dermatophytosis, or chronic widespread dermatophytosis, is an uncommon disease most often caused by Trichophyton rubrum in the immunocompromised or chronically ill host. Tinea capitis caused by T rubrum is rare in adult patients and has not, to our knowledge, been described in the HIV/AIDS population. We report the unusual case of a 62-year-old HIV-positive woman with g...
متن کاملPCR-restriction enzyme method based on the polymorphism in ribosomal-DNA for identification of the most important dermatophyte species in Iran
Background and aim: Dermatophytosis (tinea, ringworm) is the infection of skin, hair or nail that is caused by various keratinophilic fungi (dermatophytes). Dermatophytosis is a common infection throughout the world including all parts of Iran. As conventional laboratory procedures for identification of different dermatophytes are slow or lack specificity, more rapid and reliable methods are st...
متن کاملIFN-γ impairs Trichophyton rubrum proliferation in a murine model of dermatophytosis through the production of IL-1β and reactive oxygen species.
Trichophyton rubrum is the main etiological agent of dermatophytosis, an infection of the skin that affects millions of people worldwide. In this study, we developed a murine model of the dermatophytosis caused by T. rubrum in which C57BL/6 wild-type, interleukin (IL)-12(-/-), and interferon-gamma (IFN-γ(-/-)) mice were inoculated with 1 × 10(6) conidia/animal. The fungal burden, myeloperoxidas...
متن کاملA Trichophyton Rubrum Infection Model Based on the Reconstructed Human Epidermis - Episkin®
BACKGROUND Trichophyton rubrum represents the most common infectious fungus responsible for dermatophytosis in human, but the mechanism involved is still not completely understood. An appropriate model constructed to simulate host infection is the prerequisite to study the pathogenesis of dermatophytosis caused by T. rubrum. In this study, we intended to develop a new T. rubrum infection model ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Anais brasileiros de dermatologia
دوره 85 6 شماره
صفحات -
تاریخ انتشار 2010